Veno-occlusive disease

This is due to injury of the hepatic veins and presents clinically like the Budd-Chiari syndrome. It was originally described in Jamaica, where the ingestion of the toxic pyrrolizidine alkaloids in bush tea (made from plants of the genera Senecio, Heliotropium and Crotolaria) caused damage to the hepatic veins. It can be seen in other parts of the world. It is also seen as a complication of chemotherapy and total body irradiation before allogeneic bone transplantation. The development of veno-occlusive disease after transplantation carries a high mortality. Treatment is supportive with control of ascites and hepatocellular failure.

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