Principle IV Time Antibiotic Administration Correctly
For the antibiotic to be maximally effective in preventing postoperative _infection the antibiotic must be given before the surgery begins. This principle has been dearly established in many animal and human clinical trials, ‘Antibiotic administration that occurs after surgery either is markedly decreased in its efficacy or has no effect that all on preventing infection
‘I~the surgery is prolonged and an additional antibiotic dose is required, intraoperative dose intervals should be shorter (i.e., one half the usual therapeutic dose interval). Therefore penicillin should be given every 2 hours,
cephalexin every 2 hours, and dindamycin every 3 hours. This ensures that the peak plasma levels will stay adequately high and avoids periods of inadequate antibiotic levels in the tissue fluids.