Influence of disease on adverse drug reactions Medical Assignment Help

Disease processes may increase the risk and severity of adverse drug reactions in three ways.

1 Disease may lead to changes in the pharmacokinetics of a drug. A reduction in protein binding or reduced renal or hepatic clearance will potentiate the effects of certain drugs.
2 Changes in receptor density and function may occur.
For example, there is evidence that the enhanced bronchoconstrictor effects of J3-adrenoceptor antagonists in asthmatic patients may be due to a reduction (‘downregulation’) in J3-receptor number produced by longterm treatment with J3-agonists such as salbutamol.
The sensitivity of patients with myasthenia gravis to the neuromuscular blocking effects of streptomycin, neomycin or kanamycin may be due to drug-induced changes in cholinergic receptors.
3 Some inherited diseases are associated with enhanced drug toxicity.
There are also several examples of disease-related enhanced drug toxicity the nature of which is not yet understood

Some clinically important drug interactions leading to adverse effects.

Some clinically important drug interactions leading to adverse effects.

Some examples of enhanced drug toxicity associated with inherited diseases.

Some examples of enhanced drug toxicity associated with inherited diseases.

Posted by: brianna

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