The organism Candida albicans is a naturally occurring fungus ‘in the oral cavity. It rarely causes disease unless the patient’s health becomes compromised. The two most common causes of compromise are administration of antibiotics, especially penicillin, for prolonged periods and chemotherapy for leukemias and other forms of cancer. In these situations Candida organisms overgrow the oral cavity and cause a superficial infection, which usually appears intraorally as distinct white patches that can be easily rubbed off with gauze to expose an underlying red, raw surface (Fig. 16-17). Candula spp. can be easily cultured and diagnosed by their typical appearance on Gram’s stain.
Clotrunazole has a quite smal! risk of toxicity anel therefore i\ usually viewed a~. being J drug of second chotec. The usual dose of either preparation is one lozenge -t or 5 times per day for 2 weeks. I’atients usually experience rapid rcsolurlon of the signs and symptoms of candidosis but I11mt be informed that there will be a recurrence of the infection unless they continue the therapy forthe entire 14 days. If the patient has a denture, the denture hould Ill’ soaked in chlorhexldine overnight for the entire treatment.
It is important III remember that candidosis usually occurs only in medically compromised patients, Patients without histories 01 recent antibiotic therapy, cancer chemotherapy, or other types of Immunocornpronuse should he suspected of having an underlying, unt’liagnosed immunocompromistng disease. Predominant among these is acquired immunodcricicnrv vyndrome (ACID).