Bone forms 25% of the weight of a normal adult; its major mineral constituents are calcium, phosphate and, to a much lesser extent, magnesium. While obviously there is major growth in childhood, bone is not a static framework in the adult. There is a continuous process of bone remodelling with bone formation by osteoblasts and resorption by osteoclasts. While exchange of calcium between bone and plasma is only 10—15mmol daily, over 1 year 20% of total bone calcium is exchanged; minor imbalances of control of the remodelling processes can therefore lead to substantial changes in bone mass or mineralization over the years.

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PREPARATION Preparedness is the second most impoi tant factor (after prevention) in the management of medical

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